Gloria Preston, PhD

Gloria Preston, PhD



Professor, Departments of Medicine and Pathology and Laboratory Medicine

Specialty Areas: Neutrophil; ANCA-Mediated Disease; Vasculitis; Inflammation; Endothelial Injury; Proteases

Chronology:
 BS: West Virginia State College, 1985; PhD: University of Tennessee, 1991; Intramural Research Training Associate: Dr. Carl Barret, NIEHS, Laboratory of Molecular Carcinogenesis, 1992-7; Assistant Professor of Research: University of North Carolina, 1997-2000; Associate Professor: University of North Carolina, 2000-3; Adjunct Associate Professor: University of North Carolina, 2003-4; Professor: University of North Carolina, 2004-present.

Gloria Preston's research explores evidence of pathogenic effects for antineutrophil cytoplasmic autoantibodies (ANCA), most notably those with antimyeloperoxidase or antiproteinase-3 specificity, in small-vessel vasculitides (Wegener's granulomatosis, Churg-Strauss syndrome, and microscopic polyangiitis). The disease process is thought to involve complex interactions between genetic and environmental factors leading to a humoral autoimmune response against neutrophilic components. Preston's work investigates potential pathomechanistic explanations of ANCA-associated diseases. Her research specifically questions the origin of autoantibodies and how environmental exposures contribute: do the autoantibody/granulocyte interactions cause pathogenic changes in granulocyte functions, including changes in gene expression profiles and what factors are primary in the genesis of resultant endothelial lesions of the vascular endothelium.

Selected Bibliography:

Pendergraft III, WF, Pressler, DM, Jennette, JC, Falk, RJ and Preston, GA. Autoantigen complementarity: a new theory implicating complementary proteins as initiators of autoimmune disease. Journal of Molecular Medicine Jan;83(1):12-25 2005. 

Yang, JJ, Pendergraft, WF Alcorta, DA, Nachman, PH, Hogan, SL, Thomas, RP, Sullivan, P, Jennette, JC, Falk, RJ, Preston, GA. Circumvention of normal constraints on granule protein gene expression in peripheral blood neutrophils and monocytes of patients with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis. J.American Society of Nephrology, 15:210-2114, 2004. 

Pendergraft III, WF, Preston, GA, Shah R R, Tropsha, A, Jennette, JC, Falk, RJ cPR3105-206, a protein complementary to the human autoantigen Proteinase 3, triggers autoimmunity. Nature Medicine, 10: 72-79, January 2004. 

Preston, GA, Waga, I, Alcorta, DA, Sasai, H, Munger, WE, Sullivan, P, Phillips, B, Jennette, JC, Falk, RJ. Gene Expression Profiles of Circulating Leukocytes Correlate with Renal Disease Activity in IgA Nephropathy, Kidney International, 65:420-430, February 2004. 

Pendergraft III, WF, Rudolph, EH, Falk, RJ, Jahn, JE, Grimmler, M, Hengst, L, Jennette, JC, Preston, GA. Proteinase 3 sidesteps caspases and cleaves p21Waf1/Cip1/Sdi1 to induce endothelial cell apoptosis, Kidney International, 65: 75-84, January 2004.