Jennifer "Jenny" E. Flythe, MD, MPH

Jennifer "Jenny" E. Flythe, MD, MPH

7007-C Burnett-Womack
Office: 919-445-2656
Appts: 984-974-5706

UNC Health Care Profile

Assistant Professor of Medicine
Medical Director, Acute Dialysis Unit, UNC Hospitals 

Specialty Areas: Hemodialysis patient care and research; advanced kidney disease patient care; patient-centered outcomes research; epidemiology


BS Cum Laude: Duke University, 1999
MD: University of North Carolina Chapel Hill, 2006
Resident: Oregon Health & Science University, 2006-2009
Hospitalist: Kaiser Permanente 2009-2010
Nephrology Fellow: Brigham and Women’s Hospital/ Massachusetts General Hospital Joint Program, 2010-2012
MPH: Harvard School of Public Health, 2013
Clinical Faculty: Brigham and Women’s Hospital, 2013-2014
Assistant Professor of Medicine: University of North Carolina, 2014-present
Medical Director, Acute Dialysis Unit: UNC Hospitals, January 2017-present

Board Certifications: Internal Medicine and Nephrology

Dr. Flythe’s research interests include identifying and understanding modifiable mortality determinants among maintenance dialysis patients and developing innovative treatment strategies to reduce these risks. She is particularly interested in hemodialysis procedural risk factors. The majority of her work focuses on dialysis hemodynamics, fluid management, and blood pressure patterns among maintenance hemodialysis patients. She also incorporates patient-centered outcomes and patient preferences into her work to ensure that patient-stated priorities drive outcomes research.

At UNC, Dr. Flythe is involved in the management of acute and chronic kidney disease patients with a focus on hemodialysis patients at the UNC Hospital and Kidney Center and its associated outpatient dialysis facilities.

Read more about Dr. Flythe's research here.

Selected Bibliography:

Flythe JE, Narendra JH, Dorough A, Oberlander J, Ordish A, Wilkie C, Dember LM. Perspectives on Research Participation and Facilitation Among Dialysis Patients, Clinic Personnel, and Medical Providers: A Focus Group Study. Am J Kidney Dis. 2017 Dec 19. [Epub ahead of print] PMID: 29289476

Assimon MM, Wang L, Flythe JE. Intradialytic hypertension frequency and short-term clinical outcomes among individuals receiving maintenance hemodialysis. Am J Hypertens. 2017 Oct 25. [Epub ahead of print] PMID: 29077786 

Assimon MM, Flythe JE. Thirty-Day Hospital Readmissions in the Hemodialysis Population: A Problem Well Put, But Half-Solved. Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1566-1568. PMID: 28971979

Flythe JE. Turning the Tide: Improving Fluid Management in Dialysis through Technology. J Am Soc Nephrol. 2017 Aug;28(8):2260-2262. PMID: 28620082

Flythe JE, Assimon MM, Overman RA. Target weight achievement and ultrafiltration rate thresholds: potential patient implications. BMC Nephrol. 2017 Jun 2;18(1):185. PMID: 28578687

Flythe JE, Hilbert J, Kshirsagar AV, Gilet CA. Psychosocial Factors and 30-Day Hospital Readmission among Individuals Receiving Maintenance Dialysis: A Prospective Study. Am J Nephrol. 2017;45(5):400-408. PMID: 28407633 

Assimon MM, Nguyen T, Katsanos SL, Brunelli SM, Flythe JE. Identification of volume overload hospitalizations among hemodialysis patients using administrative claims: a validation study.

BMC Nephrol. 2016 Nov 11;17(1):173. PMID: 27835958 Flythe JE. Ultrafiltration Rate Clinical Performance Measures: Ready for Primetime? Semin Dial. 2016 Nov;29(6):425-434. PMID: 27528270

Assimon MM, Wenger JB, Wang L, Flythe JE. Ultrafiltration Rate and Mortality in Maintenance Hemodialysis Patients. Am J Kidney Dis. 2016 Dec;68(6):911-922. PMID: 27575009 

Schober GS, Wenger JB, Lee CC, Oberlander J, Flythe JE. Dialysis Patient Perspectives on CKD Advocacy: A Semi-structured Interview Study. Am J Kidney Dis. 2017 Jan;69(1):29-40. PMID: 27555105

Flythe JE, Assimon MM, Wenger JB, Wang L. Ultrafiltration Rates and the Quality Incentive Program: Proposed Measure Definitions and Their Potential Dialysis Facility Implications. Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1422-33. PMID: 27335126

Flythe JE, Katsanos SL, Hu Y, Kshirsagar AV, Falk RJ, Moore CR. Predictors of 30-Day Hospital Readmission among Maintenance Hemodialysis Patients: A Hospital's Perspective. Clin J Am Soc Nephrol. 2016 Jun 6;11(6):1005-14. PMID: 27151893

Flythe JE, Powell JD, Poulton CJ, Westreich KD, Handler L, Reeve BB, Carey TS. Patient-Reported Outcome Instruments for Physical Symptoms Among Patients Receiving Maintenance Dialysis: A Systematic Review. Am J Kidney Dis. 2015 Dec;66(6):1033-46. PMID: 26210069

Flythe JE, Kshirsagar AV, Falk RJ, Brunelli SM. Associations of Posthemodialysis Weights above and below Target Weight with All-Cause and Cardiovascular Mortality. Clin J Am Soc Nephrol. 2015 May 7;10(5):808-16. PMID: 25862779

Flythe JE, Brookhart MA. Fluid management: the challenge of defining standards of care. Clin J Am Soc Nephrol. 2014 Dec 5;9(12):2033-5. PMID: 25376766

Flythe JE, Xue H, Lynch KE, Curhan GC, Brunelli SM. Association of mortality risk with various definitions of intradialytic hypotension. J Am Soc Nephrol. 2015 Mar;26(3):724-34. PMID: 25270068.

Flythe JE, Curhan GC, Brunelli SM. Disentangling the ultrafiltration rate-mortality association: the respective roles of session length and weight gain. Clin J Am Soc Nephrol. 2013 Jul;8(7):1151-61. PMID: 23493384

Flythe JE, Inrig JK, Shafi T, Chang TI, Cape K, Dinesh K, Kunaparaju S, Brunelli SM. Association of intradialytic blood pressure variability with increased all-cause and cardiovascular mortality in patients treated with long-term hemodialysis. Am J Kidney Dis. 2013 Jun;61(6):966-74. PMID: 23474007

Flythe JE, Kimmel SE, Brunelli SM. Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality. Kidney Int. 2011 Jan;79(2):250-7. PMID: 20927040 

View list of publications on PubMed.