William J. Arendshorst, PhD

William J. Arendshorst, PhD

6341-B Medical Biomolecular Research Building
(919) 966-1067

Web site

Professor of Cell Biology and Physiology
Director, Laboratory of Renal Physiology and Vascular Biology

Specialty Areas: Renal Circulation, Vascular Reactivity and Signaling, Genetic Hypertension, Paracrine and autacrine agents. 

Chronology: BA, DePauw University, 1966; PhD, Indiana University, 1970; Postdoctoral Fellow, Indiana University 1970-71; Postdoctoral Fellow, UNC-Chapel Hill, 1971–74; Assistant & Associate Professor, UNC-Chapel Hill, 1974–86; Professor of Physiology, UNC-Chapel Hill, 1986 - present. 

Dr. Arendshorst’s research addresses issues centering on renal vascular reactivity to angiotensin II, endothelin, and thromboxane in genetic hypertension with particular emphasis on the involvement of nitric oxide and reactive oxygen species in the signaling pathways. Receptor subtypes and intracellular messenger systems are assessed. Investigations include in vivo blood flow experiments on whole animals. Calcium measurements in isolated microvessels and smooth muscle cells probe calcium entry channels and mobilization/release channels. Expression is studies in terms of receptors and enzyme mRNA and protein levels in isolated renal microvessels. 

Most recent studies focus on NADPH oxidase activity and reactive oxygen species as they participate in the regulation of arterial blood pressure and renal sodium excretion. Dr. Arendshorst investigates mechanisms of action on the renal vasculature and tubules.

Selected Bibliography:

Moss, NG, T Kopple and WJ Arendshorst.  Renal vasoconstriction by vasopressin V1a receptors is modulated by nitric oxide, prostanoids, and superoxide but not the ADP ribosyl cyclase CD38.  Am J Physiology Renal Physiol.  306: F1143-F1154, 2014. 

Moss, NG, PA Vogel, TE Kopple, WJ Arendshorst.  Thromboxane-induced renal vasoconstriction is mediated by the ADP-ribosyl cyclase CD38 and superoxide anion.  Am J Physiol-Renal Physiol. 305: F830-F838, 2013. http://www.ncbi.nlm.nih.gov/pubmed/23884143

Arendshorst, WJ.  Editorial Focus.  Connexin 40 mediates tubuloglomerular feedback paracrine signaling by coupling tubular and vascular cells in the renal juxtaglomerular apparatus.  Am J Physiology Renal Physiol 303: F1409-F1411, 2012.

Arendshorst, WJ and LG Navar.  Renal Circulation and Glomerular Hemodynamics.  Chapter 3 Volume 1.  Ninth Edition of Diseases of the Kidney and Urinary Tract, edited by R.W. Schrier, E. Nielson, T. Coffman and R. Falk.   Lipincott Williams and Wilkins.  2012.

Liu, Y, F Echtermeyer, F Thilo, F Theilmeier, A Schmidt, R Schuelein, BL Jensen, C Loddenkemper, V Jankowski, N Marcussen, M Gollasch, WJ Arendshorst, M. Tepel.  The proteoglycan syndecan 4 regulate transient receptor potential canonical 6 channels via RhoA/Rho-associated protein kinase signaling.  Aterioscler Thromb Vasc Biol 32: 378-385, 2012.
http://atvb.ahajournals.org/content/32/2/378.full.pdf+html

Kogan, P, K Johnson, S Feingold, N Garrett, I. Guracar, WJ Arendshorst, and PA Dayton.  Validation of dynamic contrast-enhanced ultrasound in rodent kidneys as an absolute quantitative method for measuring blood perfusion.  Ultrasound Med Biol 37: 900-908, 2011. PMCID:  PMC3285544.
http://www.sciencedirect.com/science/article/pii/S0301562911001591

Yang, D, Z Luo, S Ma, WT Wong, L Ma, J Zhong, H He, Z Zhao, T Cao, Z Yan, D Liu, WJ Arendshorst, Y Huang, M Tepel, and Z Zhu.  Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension.  Cell Metab 12: 130-141, 2010.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7MFH-50P5BMF-6&_user=130907&_coverDate=08%2F04%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000004198&_version=1&_urlVersion=0&_userid=130907&md5=7c787894546a0a29f1afd1624062f9f4&searchtype=a

Fellner, SK and WJ Arendshorst.  Complex interactions of NO/ cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle. Am J Physiol-Heart Circ Physiol   298: H144-H151, 2010.  PMCID – PMC-2806127.  http://ajpheart.physiology.org/content/298/1/H144.full.pdf+html

Arendshorst, WJ and TL Thai.  Regulation of the Renal Microcirculation by Ryanodine Receptors and Calcium-Induced Calcium Release.  Curr Opin Nephrol Hypertens 18: 40-49, 2009.  PMID-19077688. http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed/19077688?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Just, A,  L Kurtz, C de Wit, C Wagner, A Kurtz, and WJ Arendshorst.  Connexin 40 mediates the tubuloglomerular feedback contribution to renal blood flow autoregulation.  J Amer Soc Nephrol  20: 1577-1585, 2009.  PMCID:  PMC-2709687.  http://jasn.asnjournals.org/content/20/7/1577.full.pdf+html

Thai, TL, GC Churchill, and WJ Arendshorst.  NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles.  Am J Physiol-Renal Physiol 297: F510-F516, 2009.  PMCID:  PMC-2724244.  http://ajprenal.physiology.org/content/297/2/F510.full.pdf+html

Moss, NG, DA Rigeura, RM Solinga, MM Kessler, DP Zimmer, WJ Arendshorst, MG Currie, and MF Goy.  The natriuretic peptide uroguanylin elicits physiologic actions through 2 distinct topoisomers. Hypertension 53: 867-876, 2009.  PMCID:  PMC-2729689.  http://hyper.ahajournals.org/cgi/reprint/53/5/867

Thai, TL and WJ Arendshorst.  Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine.  Am J Physiol-Renal Physiol 297: F169-F176, 2009.  PMCID:  PMC-2711707.  http://ajprenal.physiology.org/content/297/1/F169.full.pdf+html

Navar, LG, WJ Arendshorst, TL  Pallone. EW Inscho, JD Imig, and PD Bell.  The Renal Microcirculation.  APS Handbook of Physiology, Microcirculation, 2nd edition, 2008, RF Tuma, WN Duran, and K Ley, Editors, Boston, Academic Press (Elsevier), pp 550-683.

Bello-Reuss, E, and WJ Arendshorst.  Kidney, Chapter 346, Volume 3, in Handbook of Cell Signaling, edited by Ralph Bradshaw and Edward Dennis, Elsevier Science, 2008.

Thai, TL and WJ Arendshorst.  ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo.  Am J Physiol-Renal Physiol  295: F360-F368, 2008.  PMCID:  PMC-2519186.  
http://www.ncbi.nlm.nih.gov/pubmed/18524860

Just, A, CL Whitten and WJ Arendshorst.  Reactive oxygen species participate in acute renal vasoconstrictor responses induced by ETA- and ETB-receptors. Am J Physiol-Renal Physiol  294: F719-28, 2008.  PMID-18256310.  http://ajprenal.physiology.org/cgi/reprint/294/4/F719 .

Fellner, SK and WJ Arendshorst.  Angiotensin II-stimulated calcium entry mechanisms in afferent arterioles:  Role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange.  Am J Physiol-Renal Physiol 294:F212-F219, 2008. PMID-17977908.  http://ajprenal.physiology.org/cgi/content/full/294/1/F212

Peng Z and WJ Arendshorst.  Activation of phospholipase Cγ1 protects renal arteriolar VSMCs from H2O2-induced cell death.  Kidney Blood Pressure Res 31: 1-9, 2008.  PMCID: PMC2821434..
http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu/pubmed/18004076?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Just A and WJ Arendshorst.  A novel mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice.  Am J Physiol - Renal Physiol 293: F1489-F1500, 2007.  PMID-17728380. http://ajprenal.physiology.org/cgi/reprint/293/5/F1489

Thai TL, SK Fellner and WJ Arendshorst.  ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo.  Am J Physiol - Renal Physiol 293: F1107-F1114, 2007.  PMID- 17652368.  http://ajprenal.physiology.org/cgi/content/full/293/4/F1107

Vågnes, OB, BM Iversen and WJ Arendshorst.  Short-term Ang II produces renal vasoconstriction independent of TP receptor activation and TxA2 / isoprostane production.  Am J Physiol-Renal Physiol 293: F860-F867, 2007.  PMID- 17567934.  http://ajprenal.physiology.org/cgi/content/full/293/3/F860

Fellner, SK and WJ Arendshorst.  Voltage-gated Ca2+ entry and ryanodine receptor Ca2+-induced Ca2+ release in preglomerular arterioles.  Am J Physiol-Renal Physiol 292:  F1568-F1572, 2007.  PMID- 17190906. http://ajprenal.physiology.org/cgi/reprint/292/5/F1568

Fellner SK and WJ Arendshorst.  Endothelin-A and -B receptors, superoxide, and Ca2+ signaling in afferent arterioles.  Am J Physiol-Renal Physiol 292: F175-F184, 2007.  PMID- 16788136. http://ajprenal.physiology.org/cgi/reprint/292/1/F175

Just A, AJ Olson, CL Whitten and WJ Arendshorst.  Superoxide mediates acute renal vasoconstriction produced by angiotensin II and catecholamines by a mechanism independent of nitric oxide.  Am J Physiol Heart Circ Physiol 292: H83-H92, 2007.  PMID- 16951043.  http://ajpheart.physiology.org/cgi/reprint/292/1/H83

Peng, Z and WJ Arendshorst.  PLC expression and activity in smooth muscle cells of renal arterioles and aorta of young SHR during culture.  Am J Hypertens 20: 520-526, 2007.  PMID- 17485014. http://linkinghub.elsevier.com/retrieve/pii/S0895-7061(07)00050-7

Peng Z, A Dang and WJ Arendshorst.  Increased expression and activity of phospholipase C in renal arterioles of young spontaneously hypertensive rats.  Am J Hypertens 20: 38-43, 2007.  PMID- 17198910.  http://linkinghub.elsevier.com/retrieve/pii/S0895-7061(06)00428-6

Just A and WJ Arendshorst.  Nitric oxide blunts myogenic autoregulation in rat renal but not skeletal muscle circulation via tubuloglomerular feedback.  J Physiol 569: 959-974, 2005.  
PMCID:  PMC-1464274.  http://jp.physoc.org/cgi/reprint/569/3/959
     Comment in:  J Physiol. 569:713, 2005. http://www.pubmedcentral.nih.gov.libproxy.lib.unc.edu/articlerender.fcgi?tool=pubmed&pubmedid=16239262

Fellner, SK and WJ Arendshorst.  Angiotensin II, reactive oxygen species and Ca2+ signaling in afferent arterioles  Am J Physiol-Renal Physiol  289: F1012-F1019, 2005.  PMID- 15942049.  
http://ajprenal.physiology.org/cgi/reprint/00144.2005v1

Facemire, C, WJ Arendshorst.  Calmodulin mediates norepinephrine-induced receptor-operated calcium in preglomerular resistance arteries.  Am J Physiol-Renal Physiol 289: F127-F136, 2005.  PMID- 15701815. http://ajprenal.physiology.org/cgi/content/full/289/1/F127

Vagnes, O, FH Hansen, JJ Feng, BM Iversen, and WJ Arendshorst.  Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states.  Am J Physiol – Renal Physiol 288: F1249-F1256, 2005.  PMID- 15657301.  
http://ajprenal.physiology.org/cgi/content/full/288/6/F1249

Just, A, AJM Olson, JR Falck, WJ Arendshorst.  Nitric oxide and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat.  
Am J Physiol-Regul Integr Comp Physiol 288: R1168-R1177, 2005.  PMID- 15618347.   
http://ajpregu.physiology.org/cgi/content/full/288/5/R1168

Fellner, SK and WJ Arendshorst.  Angiotensin II Ca2+ signaling in rat afferent arterioles: Stimulation of cyclic ADP ribose and IP3 pathways.  Am J Physiol- Renal Physiol  288: F785-F791, 2005.  
PMID- 15598842.  http://ajprenal.physiology.org/cgi/reprint/288/4/F785

Boffa, JJ, and WJ Arendshorst.  Maintenance of renal vascular reactivity contributes to acute renal failure during endotoxemic shock.  J Amer Soc Nephrol 16: 117-124, 2005.  PMID- 15563566.  
http://www.jasn.org/cgi/content/abstract/16/1/117