Center for Excellence - Vasculitis and GN

The UNC Kidney Center is a Center for Excellence for Glomerular Disease and Vasculitis, providing clinical care for patients and leading research studies.

Clinical Care: Vasculitis and GN Providers

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Research Studies

ANCA Glomerulonephritis: From Molecules to Man

Funding Source:  NIDDK/NIH

This program project consists of three projects and two cores focusing on a broad spectrum of research on anti-neutrophil cytoplasmic autoantibody (ANCA) necrotizing and crescentic glomerulonephritis and small vessel vasculitis (SVV).  The scope of the investigation and the diversity of the investigators allow for an integrated evaluation of myeloperoxidase (MPO) and proteinase 3 (PR3) autoimmune response.  Core A gathers biologic samples and clinical information from patients with ANCA glomerulonephritis, as well as from other individuals as needed for other disease and healthy controls.

Systems-wide Temporal Observation of Patients with Systemic Lupus Erythematosus (STOP SLE)

Funding Source: Broad Institute

The purpose of this study is to understand response to treatment in patients with systemic lupus erythematosus (SLE) by analyzing known and unknown factors over time through DNA sequencing, RNA sequencing, proteomics, and measurements of known pathogenic factors from cells in blood and serum, plasma and urine. The long-term objectives of this study aim to identify new mechanistic insights through the development of a systems-wide quantitative model of disease dynamics during relapse. This innovative and state-of-the-art approach, which we call The S.T.O.P. SLE (Systems-wide Temporal Observation of Patients with SLE) Study, will reveal unknown molecular mechanisms underlying SLE.

Cure Glomerulonephropathy (CureGN) Study

Funding Source: NIDDK/NIH

CureGN is a multicenter cohort study of glomerular disease patients funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes for Health (NIH).The CureGN project will study 2,400 children and adults with the following glomerular diseases: minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and IgA nephropathy (IGAN).Participants will be followed longitudinally to better understand the causes of disease, response to therapy, and disease progression, with the ultimate objective to cure glomerulonephropathy.

Nephrotic Syndrome Study Network (NEPTUNE)

Funding Source: Office of Rare Diseases/NephCure/NIDDK/NIH

NEPTUNE is multi-center, multidisciplinary research and education platform that brings together clinical and translational scientists and two lay research and patient education foundations to better study focal segmental glomerulosclerosis, membranous nephropathy and minimal change disease. The goal of this project is to assemble and characterize an incident population of kidney disease patients into a prospective research cohort made available to network and external investigators to conduct clinical and translational research aimed at new preventative, diagnostic and therapeutic targets for glomerular disease causing nephrotic syndrome.