Adjunct Faculty
Chronology: BA: University of Pennsylvania, 1995; M.M.S.: MCP Hahnemann University, 1997; MD: Hahnemann School of Medicine, Medical College of Pennsylvania, 2001; Resident: University of North Carolina, 2001-2004; Nephrology Fellow: Duke University Medical Center, 2004-2006; Associate Medical Director of Dialysis Unit: Nephrologist for NaphCare, Inc, 2007-present; Quintiles Global CRO: Oct 2006-2017; Covance by Labcorp: 2017-present.
Dr. Gillespie is a board-certified nephrologist who is currently a Vice President at Covance Global CRO and the Therapeutic Head of Nephrology, supporting sponsors on the development of new drugs and devices for CKD patients. She is also on the Board of Directors at the Kidney Health Initiative, a public-private partnership between the FDA and American Society of Nephrology. Dr. Gillespie, an Associate Medical Director at a local dialysis unit, completed her residency in internal medicine at the University of North Carolina and her nephrology fellowship at Duke University Medical Center.
She currently serves on several KHI Workgroups: Barriers to CKD patient participation in CV Trials, Endpoints for IgA Nephropathy, and Endpoints for FSGS, Endpoints to C3G. She was/is actively involved in the NKF/FDA Scientific Workshop on Clinical Trial Considerations for Early Common CKD (Workgroup Co-Chair), NKF/FDA/EMA Workshop on Renal Endpoints (Stakeholder Committee), NKF CKD Patient Registry (Scientific Advisory Board), UNC’s PCORI grant on Building Research Capacity in Dialysis (Stakeholder Advisory Board), an invited Workgroup participant for the SONG Initiative (Standardised Outcomes in Nephrology), on the Regional Medical Ad Board for NKF, and the FDA and NephCure’s Clinical Trial Collaborative (Workgroup Co-Chair).
Publications
J. Ishida, C. Chauhan, B. Gillespie, K. Gruchalla, P. McCullough, S. Quella, A. Romero, P. Rossignol, D. Wheeler, M. Malley, M. West, C. Herzog. “Understanding and Overcoming the Challenges Related to Cardiovascular Trials Involving Patients with Kidney Disease”. CJASN April 2021, CJN.17561120; DOI: https://doi.org/10.2215/CJN.17561120
L. Barisoni, J. Barratt,K. Campbell, Eva, B. Gillespie, D. Gipson, M. Jardine, E. Kamil, M. Kretzler, L. Lee, Levtchecnk, Mehr, P. Nachman, et al. “Innovating and invigorating the clinical trial infrastructure for glomerular diseases”. Kidney International (2021) 99, 519-523 https://doi.org/10.1016/j.kint.2020.09.038
Ennis, Gillespie, Letovsky, “CKD Screening Among At-Risk Individuals is Inadequate: An Analysis from a National Laboratory Database”; abstract at NKF Spring Clinical Meeting, Mar 2020
Gillespie, “Patients as Partners in Renal Clinical Development”, invited article for Kidney News, Oct 2020
A.Thompson, K. Carroll, L. Inker, J. Floege, V.Perkovic, S. Boyer, R. Major, J. Schimpf, J. Barratt, D. Cattran, B.Gillespie, A. Kausz, A. Mercer, H. Reich, B. Rovin, E. Silverman , M. West, P.Nachman. “Proteinuria Reduction as a Surrogate Endpoint in Trials of IgA Nephropathy”, CJASN Jan 2019
J Ennis, Dajie Luo, B Gillespie “Chronic Kidney Disease Monitoring in Routine Clinical Practice: An Analysis of a National Laboratory Database”, Abstract Supplement, ASN Kidney Week 2018
Gillespie, “Selected Lessons Learned in Dialysis Trials: A Practical Perspective”, Poster, IDEAS Meeting Innovations in Dialysis, Aug 2018
Cressman M, Ennis J, Goldstein B, Gourgiotis, Luo D, Puri M, Gillespie B. “CKD Prevalence and Risk are Higher in Adults with Type 2 vs Type 1 Diabetes: An Assessment of 1.5 Million Patients Recently Evaluated in US Clinical Practices” abstract and poster at the ADA June 2018
Turner JR, Caveney E, Gillespie B, Karnad D, Kothari S, Metz A, Keller L.“With regard to the papers by Kumar et al. and de Leeuw and de Boer addressing the cardiovascular safety and efficacy of anti-diabetic drugs”. letter to editor in European Heart Journal-Cardiovascular Pharmacotherapy, doi:10.1093/ehjcvp/pvw047, Jan 2017
Gottlieb K, Turner JR, Gillespie BS, Hussain F. „Bowel Preparations for Colonscopy: A Regulatory Perspective“ DOI: 10.1177/2168479015577868. Therapeutic Innovation & Regulatory Science online print April 2015.
Tebbi C, Costanzi J, Shulman R, Dreisbach L, Jacobs B, Blaney M, Ashby M, Gillespie BS, Begelman S. “A Phase III, Open-Label, Single-Arm Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters” Journal of Vascular and Interventional Radiolog, May 2011
Tumlin J, Goldman J, Spiegel D, Roeor D, Ntoso KA, Blaney M, Jacobs J, Gillespie BS, Begelman S. “A Phase III randomized, Double-Blind, Placebo-Controlled Study of Tenecteplase for Improvement of Hemodialysis Catheter Function: TROPICS 3 online print Feb 4, 2010 Clinical Journal of the American Society of Nephrology doi: 10.2215/CJN.06520909
Fishbane S, Milligan S, Lempert K, Hertel J, Wetmore J, Oliver M, Blaney M, Gillespie BS, Jacobs J, Begelman S. “Improvement of Hemodialysis Catheter Function with Tenecteplase: A Phase III Open-Label Study: TROPICS 4 J Thromb Thrombolysis. 2010 Jul 11; PMID: 20623319
Gabrail N, Sandler E, Charu V, Anas N, Lim E, Blaney M, Ashby M, Gillespie BS, Begelman S. “A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Tenecteplase for Restoration of Function in Central Venous Catheters” Journal of Vascular and Interventional Radiology, Dec 2010: 21(12)1852-1858
Inrig JK, Gillespie B, Briley LP, Patel U, She L, Easton D, Topol E, Szczech LA. ”The risk of cardiovascular outcomes among subjects with acute coronary syndromes and greater than normal estimated glomerular filtration rates” Clinical Journal of the American Society of Nephrology Nov 2007. Doi: 10.2215/CJN.00930207
Inrig JK, Patel U, Briley LP, She L, Gillespie B, Easton D, Topol E, Szczech LA. “Mortality, Kidney Disease, and Cardiac Procedures following Acute Coronary Syndrome” Nephrology Dialysis Transplantation, (2007) 0: 1–7 doi: 10.1093/ndt/gfm689 (advanced access published Nov 2007)
Inrig JK, Patel UD, Gillespie BS, Hasselblad V, Himmelfarb J, Reddan D, Lindsay RM, Winchester JF, Stivelman J, Toto R, Szczech LA. “Relationship Between Interdialytic Weight Gain and Blood Pressure Among Prevalent Hemodialysis Patients”. American Journal of Kidney Disease. 50 (1):108-118 July 2007
Inrig JK, Oddone E, Hasselblad V, Gillespie B, Patel U, Reddan D, Toto R, Himmelfarb J, Winchester JF, Stivelman J, Lindsay RM, Szczech LA. “Association of Intradialytic Blood Pressure Changes with Hospitalization and Mortality Rates in Prevalent ESRD Patients.” Kidney International. 71(5):454-461 March 2007
Gillespie, B, Inrig JK, Szczech, LA. “Anemia Management in Chronic Kidney Disease”, Hemodialysis International.11(1):15-20 Jan 2007
SC Dixon, BJ Soriano, RM Lush, MM Borner, WD Figg. “Apoptosis: Its role in the development of malignancies and as a novel therapeutic target.” Annals of Pharmacotherapy. 31(1):76-82, Jan. 1997
Szczech LA, Golub E, Springer G, Augenbraun M,Young M, GandhiM,Gillespie BS, Anastos K. “HAART reduces albuminuria excretion rate among women with HIV-infection” manuscript submitted
Abstracts and Presentations
Tumlin J, Goldman J, Spiegel D, Roeor D, Ntoso KA, Blaney M, Jacobs J, Gillespie BS, Begelman S. “A Phase III randomized, Double-Blind, Placebo-Controlled Study of Tenecteplase for Improvement of Hemodialysis Catheter Function: TROPICS 3” Free Communication Session (oral presentation), American Society of Nephrology Meeting, Oct. 2009; poster at Amer Soc Health-System Pharmacists Clinical Meeting Dec 2009
Fishbane S, Milligan S, Lempert K, Hertel J, Wetmore J, Oliver M, Blaney M, Gillespie BS, Jacobs J, Begelman S. “Improvement of Hemodialysis Catheter Function with Tenecteplase: A Phase III Open-Label Study: TROPICS 4” American Society of Nephrology Meeting, Oct. 2009; poster at ANNA (May 2010), ASHP (Dec 09) and SIR (Mar 10)
Gabrail N, Sandler E, Charu V, Anas N, Lim E, Blaney M, Ashby M, Gillespie BS, Begelman S. “A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Tenecteplase for Restoration of Function in Central Venous Catheters” oral presentation American Society of Hematology Meeting Dec. 2009 and SIR March 2010
Tebbi C, Costanzi J, Shulman R, Dreisbach L, Jacobs B, Blaney M, Ashby M, Gillespie BS, Begelman S. “A Phase III, Open-Label, Single-Arm Study of Tenecteplase for Restoration of Function in Dysfunctional Central Venous Catheters” American Society of Hematology Meeting Dec. 2009 and oral presentation at SIR March 2010
Gillespie B, Inrig JK, Briley LP, Patel U, She L, Easton D, Topol E, Szczech LA. ”The risk of cardiovascular outcomes among patients with acute coronary syndromes and greater than normal estimated glomerular filtration rates” Free Communication Session (oral presentation), American Society of Nephrology Meeting, Nov. 2006
Inrig JK, Gillespie B, Hasselblad V, Oddone E, Patel U, Szczech LA. “Outcomes Associated with Blood Pressure Changes with Hemodialysis among Prevalent ESRD Patients.” Abstract, SSCI Nephrology Forum 2006 and National Kidney Foundation Clinical Meeting 2006
Inrig JK, Briley LP, Patel U,, She L, Gillespie B, Easton D, Topol E, Szczech LA. “The risk of acute renal failure, progression of chronic kidney disease, and mortality associated with percutaneous cardiac procedures among patients with acute coronary syndrome” American Society of Nephrology Meeting, Nov. 2006
P Banerjee, S Attarchi, M Ovsiowitz, BJ Soriano, A Singh, M Young, J Morgan, R Boynton, L Borowsky, S Dhillon, JC Reynolds. “Difference in nutrition and environmental exposures in patients with Barrett’s and GERD.” American Gastroenterology Association Digestive Diseases Week, Abstract 457, May 2001
ST Melman, BJ Soriano, C Koepke, RD Anbar. “Where do the children play?” Ambulatory Pediatric Association Abstracts, May 1997
