Skip to main content

Principal Investigator: Amy Mottl, MD
Sponsors: National Institutes of Health and National Institute of Diabetes and Digestive and Kidney Diseases
Age Range: 18 years and older
Status: Enrolling

Purpose: The purpose of this research study is to learn more about kidney disease in adults with type 2 diabetes, also known as diabetic kidney disease. Diabetic kidney disease is usually diagnosed by the presence of proteinuria and how well the kidneys are filtering toxins. Knowledge about the presence of retinopathy, diabetic damage to the eye, can also be helpful in diagnosis. Diabetic kidney disease can also be diagnosed by a kidney biopsy, a surgical procedure that removes a small piece of kidney tissue to be looked at under a microscope. Kidney biopsies are usually not done on patients with diabetic kidney disease but we would like to see if biopsy results are a useful tool to diagnose and treat diabetic kidney disease. We would also like to see if the severity of retinopathy can tell us anything about the nature or severity of kidney disease found on kidney biopsy.

Study Procedures: Participants will have 3 separate study visits: 1) an ultrasound guided kidney biopsy, which will take an entire day, 2) an Iohexol measured glomerular filtration rate test which will take about 6 hours, and 3) retinal photographs of the eyes which take about 2 hours. The participant’s eyes will be dilated for these photographs.

Participation: There are 3 study visits.

For more information, please contact:

Sandy Grubbs