Dialysis Research

Fluid and blood pressure management in the dialysis population

Sub-optimal fluid and blood pressure management both contribute to the high rates of hospitalization and death experienced by individuals receiving hemodialysis. We conduct observational and prospective studies related to the following fluid-related topic areas: extracellular volume management, dialytic fluid removal (ultrafiltration) rate, dialysis frequency and duration, sodium management, and intradialytic hypotension and hypertension.

Clinical Trial: Ultrafiltration profiling and outcomes among individuals on maintenance hemodialysis

Interviews: Fluid Removal During Hemodialysis
View Part One and Part Two 

Ultrafiltration Rate Calculator 

Patient-reported outcomes and patient preferences in the dialysis population

Patient-reported outcomes (PROs) such as symptoms, quality of life, or patient perceived health status are reports of the status of a patient’s condition that come directly from the patient, without amendment or interpretation of the patient’s response by a clinician or anyone else. Our PRO research aims to improve the quality of dialysis care delivery and patient outcomes through development and implementation of PRO measures.

Stakeholder engagement to inform, facilitate and improve dialysis research

Dialysis ResearchEffective stakeholder engagement in research design, implementation and dissemination has the potential to enhance research quality and the clinical uptake of research findings. Dialysis research, in particular, involves numerous key stakeholders including patients, care partners, dialysis clinic personnel, medical providers, dialysis organization professionals, and healthcare payers. Our stakeholder engagement research focuses on effective stakeholder engagement as a means to improve both research processes and clinical care in dialysis clinics.

Patient-Centered Outcomes Research Institute (PCORI) Engagement AwardBuilding Research Capacity in the Dialysis Community at the Local Level

Medication safety and effectiveness in the dialysis population

Individuals receiving maintenance dialysis therapy possess a tremendous comorbid disease burden that typically requires treatment with multiple medications (on average, 10-12 medications per day). The safety and efficacy of many marketed medications have not been studied via randomized controlled trials in the dialysis population, a population with special drug dosing considerations. In our pharmacoepidemiologic research, we use administrative claims and electronic health record data to conduct large-scale comparative safety and effectiveness studies in efforts to provide evidence to guide medication prescribing in the dialysis population.