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Publications and Grants

Grant Funding

  • R01DK132328: Modulation of VSMC phenotype through the Insulin Receptor Substrate-1/Kruppel-like factor-4 signal transduction pathway: a Novel Target for AVF Dysfunction” – Xi/Roy-Chaudhury (MPI)
  • R01 HL119371: “Synthetic Mesenchymal Stem Cell Niches for Vascular Therapy” – Roy-Chaudhury (Site PI)
  • U01EB035996: “Vertically Integrated Approach to Design a Biologically and Mechanically Optimized Vascular Conduit for Dialysis Vascular Access” – Roy-Chaudhury/Crapo/Wang
  • R44DK139895: “Platform for Extended Kidney Preservation Via Subnormothermic Perfusion” – Neusner/Roy-Chaudhury/Barbas (MPI)
  • 1I01BX006169-01 (VA Merit): “Hemodynamics, Uremia, Vascular Biology and Bioengineering: Creating the Ideal HD Vascular Access system” – Roy-Chaudhury (PI)
  • R25DK131344: “Transforming Kidney Care through Skill and Workforce Development: the North Carolina Kidney Technology Incubator (NC-KTI)” – Roy-Chaudhury (MPI)
  • R43DK137665: “A Smart Simulator for Metrics-based Cannulation Skills Training for Hemodialysis” – Roy-Chaudhury/Singapogu/Peterson
  • Bayer Investigator Initiated Grant: “EFFEKTOR, a randomized study of Finerenone in Kidney Transplant Recipients” – Mottl/Roy-Chaudhury (MPI)
  • ICS-UNC: “GraphenE oxide membraNES for portable kidney dialysIS (GENESIS)” – Dingemans/Roy-Chaudhury/Orlando
  • ICS-UNC: “Engineered human microvessels for patient stratification” – Polachek/Roy-Chaudhury
  • R21DK14482 (JIT submitted): “Leveraging “Smart Stent “Platform Technologies for AVF Maturation and More.” – Roy-Chaudhury/Schulz

Selected Manuscripts

Translational Science

  1. He Y, Wei G, Greene T, Imrey PB, Northrup H, Radeva MK, Beck GJ, Gassman JJ, Kraiss LW, Robbin M, Roy-Chaudhury P, Cheung AK, Berceli SA, Shiu YT; Hemodialysis Fistula Maturation (HFM) Study Group. Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula. Sci Rep. 2025 Feb 19;15(1):6131. doi: 10.1038/s41598-025-89896-z. PMID: 39972115; PMCID: PMC11840087.
  2. Liu Z, Bible J, Petersen L, Zhang Z, Roy-Chaudhury P, Singapogu R. Relating process and outcome metrics for meaningful and interpretable cannulation skill assessment: A machine learning paradigm. Comput Methods Programs Biomed. 2023 Jun;236:107429. doi: 10.1016/j.cmpb.2023.107429. Epub 2023 Apr 18. PMID: 37119772; PMCID: PMC10291517.
  3. Li Y, He Y, Falzon I, Fairbourn B, Tingey S, Imrey PB, Radeva MK, Beck GJ, Gassman JJ, Roy-Chaudhury P, Berceli SA, Cheung AK, Shiu YT; Hemodialysis Fistula Maturation Study. Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation. Kidney Int Rep. 2022 May 21;7(8):1905-1909. doi: 10.1016/j.ekir.2022.05.016. PMID: 35967120; PMCID: PMC9366358.
  4. Li L, Uriyanghai U, Wai C, Yuan H, Livingston EW, Bahnson EM, Sudarsanam V, Haddad S, Roy-Chaudhury P, Griffith BE, Xi G. Temporal evolution of hemodynamics in murine arteriovenous fistula: a micro-CT based computational fluid dynamics study. PLoS Comput Biol. 2025 Aug 18;21(8):e1012985.
  5. Arteaga EC, Wai C, Uriyanghai U, Rudraraju M, Su H, Sudarsanam VA, Haddad SO, Poulton JS, Roy-Chaudhury P, Xi G. Characterization of Protein Expression and Signaling Pathway Activation That May Contribute to Differential Biological Functions in Porcine Arterial and Venous Smooth Muscle Cells. Int J Mol Sci. 2025 Mar 28;26(7):3110.
  6. Xi G, Shen X, Wai C, White MF, Clemmons DR. Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization. J Biol Chem. 2019 Feb 15;294(7):2407-2421.
  7. Xi G, Wai C, White MF, Clemmons DR. Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation. J Biol Chem. 2017 Feb 3;292(5):2009-2020. doi: 10.1074/jbc.M116.758987. Epub 2016 Dec 21. PMID: 28003360; PMCID: PMC5290970.

Technology Development

  1. Rathod M, Stack RN, Kubik SE, Huang SA, Whitworth CP, Aw WY, Doherty EL, Meehan SM, Roy-Chaudhury P, Polacheck WJ. Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction. Adv Sci (Weinh). 2025 Jun 20:e17091. doi: 10.1002/advs.202417091. Epub ahead of print. PMID: 40538277
  2. Rathod ML, Aw WY, Huang S, Lu J, Doherty EL, Whithworth CP, Xi G, Roy-Chaudhury P, Polacheck WJ. Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure. Small. 2024 Jun;20(24):e2307901. doi: 10.1002/smll.202307901. Epub 2024 Jan 7. PMID: 38185718; PMCID: PMC11168887.
  3. Abraham N, Gao Q, Kahan R, Alderete IS, Wang B, Howell DN, Anwar IJ, Ladowski JM, Nakata K, Jarrett E, Hlewicki K, Cywinska G, Neill R, Aardema C, Gerber DA, Roy-Chaudhury P, Hughes BA, Hartwig MG, Barbas AS. Subnormothermic Oxygenated Machine Perfusion (24 h) in DCD Kidney Transplantation. Transplant Direct. 2024 May 24;10(6):e1633. doi: 10.1097/TXD.0000000000001633. PMID: 38807861; PMCID: PMC11132391.
  4. Maloney SE, Grayton QE, Wai C, Uriyanghai U, Sidhu J, Roy-Chaudhury P, Schoenfisch MH. Nitric Oxide-Releasing Hemodialysis Catheter Lock Solutions. ACS Appl Mater Interfaces. 2023 Jun 21;15(24):28907-28921. doi: 10.1021/acsami.3c02506. Epub 2023 Jun 7. Erratum in: ACS Appl Mater Interfaces. 2023 Jul 19;15(28):34321. doi: 10.1021/acsami.3c09211. PMID: 37285144

Clinical Research

  1. Winkelmayer WC, Burke SK, Chertow GM, Eckardt KU, Luo W, Minga T, Sarnak MJ, Roy-Chaudhury P. Vascular Access Thrombosis Events in Patients With Dialysis-Dependent CKD Treated With Vadadustat or Darbepoetin Alfa: The INNO2VATE Trial Program. Kidney Med. 2025 Mar 19;7(5):100997. doi: 10.1016/j.xkme.2025.100997. PMID: 40330911; PMCID: PMC12051538.
  2. Razavi MK, Balamuthusamy S, Makris AN, Hoggard JG, Harduin LO, Roy-Chaudhury P, Jones RG; WAVE Trial Investigators. Six-month safety and efficacy outcomes from the randomized-controlled arm of the WRAPSODY Arteriovenous Access Efficacy (WAVE) trial. Kidney Int. 2025 Apr;107(4):740-750. doi: 10.1016/j.kint.2025.01.006. Epub 2025 Jan 23. PMID: 39862972.
  3. Ravi KS, Tumlin JA, Roy-Chaudhury P, Koplan BA, Costea AI, Kher V, Williamson D, McClure CK, Charytan DM, Mc Causland FR; MiD Investigators and Committees. Association of Dialysate Bicarbonate with Arrhythmia in the Monitoring in Dialysis Study. Kidney360. 2024 Oct 1;5(10):1490-1499. doi: 10.34067/KID.0000000000000537. Epub 2024 Aug 6. PMID: 39480910; PMCID: PMC11556930..
  4. Soomro QH, Koplan BA, Costea AI, Roy-Chaudhury P, Tumlin JA, Kher V, Williamson DE, Pokhariyal S, McClure CK, Charytan DM; MiD Investigators. Arrhythmia and Time of Day in Maintenance Hemodialysis: Secondary Analysis of the Monitoring in Dialysis Study. Kidney Med. 2024 Feb 20;6(4):100799. doi: 10.1016/j.xkme.2024.100799. PMID: 38572395; PMCID: PMC10987926.
  5. Agarwal AK, Roy-Chaudhury P, Mounts P, Hurlburt E, Pfaffle A, Poggio EC. Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis: A Randomized, Double-Blind, Active-Control, Phase 3 Study. Clin J Am Soc Nephrol. 2023 Nov 1;18(11):1446-1455. doi: 10.2215/CJN.0000000000000278. Epub 2023 Sep 6. PMID: 37678222; PMCID: PMC10637459.

Training

  1. Sparks MA, Burgner A, Baker A, Chong CC, Dawoud D, Hull J, Jain K, Kant S, Oza-Gajera B, Ramos CR, Pitre PM, Sachdeva B, Voiculescu A, Leigh KA, Kessler J, Perry SB, Roy-Chaudhury P, Niyyar VD. Current State and Future Direction of Vascular Access Training in the United States. Clin J Am Soc Nephrol. 2025 Apr 1;20(4):539-546. doi: 10.2215/CJN.0000000646. Epub 2025 Feb 19. PMID: 39970003; PMCID: PMC12007823.
  2. Singapogu R, Chowdhury A, Roy-Chaudhury P, Brouwer-Maier D. Simulator-based hemodialysis cannulation skills training: a new horizon? Clin Kidney J. 2020 Dec 6;14(2):465-470. doi: 10.1093/ckj/sfaa206. PMID: 33623670; PMCID: PMC7886575.

Policy and Advocacy

  1. Niyyar VD, Beathard GA, McLennan G, Sparks MA, Bryant K, Delgado C, Jefferson N, Kessler J, Leigh K, Stark S, Roy-Chaudhury P; Transforming Dialysis Access Together (TDAT). Transforming Dialysis Access Together: A Multidisciplinary, Cross-Cutting, Patient-Centered Initiative. Clin J Am Soc Nephrol. 2024 Oct 1;19(10):1338-1340. doi: 10.2215/CJN.0000000000000569. Epub 2024 Aug 14. PMID: 39141434; PMCID: PMC11469781.
  2. Murray R, Roy-Chaudhury P, Parikh S. American Society of Nephrology Efforts to Address Challenges Highlighted in Recent Joint Global Consensus Statement Issued with European Renal Association and International Society of Nephrology. J Am Soc Nephrol. 2024 Aug 1;35(8):1127-1129. doi: 10.1681/ASN.0000000000000392. Epub 2024 Apr 30. PMID: 39248632; PMCID: PMC11377797..
  3. Josephson MA, Payton J, Crews DC, Smith NC, Roy-Chaudhury P, Lynch F. Working Together to Promote Kidney Health. Nephrol Nurs J. 2024 Jul-Aug;51(4):333-368. PMID: 39230463.
  4. Francis A, Harhay MN, Ong ACM, Tummalapalli SL, Ortiz A, Fogo AB, Fliser D, Roy-Chaudhury P, Fontana M, Nangaku M, Wanner C, Malik C, Hradsky A, Adu D, Bavanandan S, Cusumano A, Sola L, Ulasi I, Jha V; American Society of Nephrology; European Renal Association; International Society of Nephrology. Chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol. 2024 Jul;20(7):473-485. doi: 10.1038/s41581-024-00820-6. Epub 2024 Apr 3. PMID: 38570631.

Published Abstracts

  1. Shariff SM, Haddad S,, Lee S, Kieu S, Mathew G, Xi G, Roy-Chaudhury P. Use of a digital stethoscope to evaluate arteriovenous fistulae befor and after intervention. J Am Soc Nephrol 2024; 35:79. [SA-OR43]
  2. Uriyanghai U, Bahnson EM, Wai C, Li L, Livingston EW, Sudarsanam S, Haddad S, Su H, Arteqaga EC, Griffith BE, Roy-Chaudhury P, Xi G. Light sheet fluorescence microscopy: a novel tool for three-dimensional optical reconstruction of mouse arteriovenous fistulae in control and uremic animals. J Am Soc Nephrol 2024; 35:78. [SA-OR38]
  3. Su H, Arteaga EC, Wai C, Uriyanghai U, Sudarsanam V, Haddad S, Bahnson EM, Roy-Chaudhury P, Xi G. Uremic serum results in and activation and phenotypic switch of pig venous and arterial smooth muscle cells (SMCs). J Am Soc Nephrol 2024; 35:614. [FR-PO497]
  4. Uriyanghai U, Wai C, Su H, Arteaga EC, Sudarsanam VA, Haddad S, Bahnson EM, Roy-Chaudhury P, Xi G. Uremia, angioplasty injury, and vessel type (artery vs. vein) activate differential gene expression and pathway profiles. J Am Soc Nephrol 2024; 35:614. [FR-PO498]
  5. Arteaga EC, Su H, Wai C, Uriyanghai U, Sudarsanam VA, Haddad S, Roy-Chaudhury P, Xi G. Differential gene expression and signal pathways activation lead to differences in cell proliferation and migration of venous and arterial pig smooth muscle cells. J Am Soc Nephrol 2024; 35:615. [FR-PO499]
  6. Rathod M, Aw WY, Coherty EL, Xi G, Roy-Chaudhury P, Polacheck WJ. A microfluidic approach for cardiovascular risk stratification in CKD and ESKD patients. J Am Soc Nephrol 2023; 34:726. [SA-PO-019]
  7. Ravi KS, Tumlin JA, Roy-Chaudhury P, Charytan DM, McCausland FR, Monitoring in Dialysis Study Group. The association of dialysate bicarbonate with cardiac arrhythmia in the Monitoring in Dialysis (MiD) Study. J Am Soc Nephrol 2023; 34:164. [TH-PO266]
  8. Uriyanghai U, Wai C, Sidhu J, Sudarsanam VA, Celdran-Bonafonte D, Arteago EC, Lewis TB, Massoud ND, Shipley S, Hostetter TH, Xi, G, Roy-Chaudhury P. A Novel Titratable Pig Model of Mild, Moderate, and Severe CKD. J Am Soc Nephrol 2023; 34:679. [FR-PO984]
  9. Sidhu J, Lewis TG, Wai Christine, Jarrouj A, Saum KL, Celdran-Bonafonte D, Campos B, Arteaga EC, Xi G, Uriyanghai U, Roy-Chaudhury P. Uremia and a Lack of Krüppel Like Factor-2 (KLF-2) are Responsible for an Inadequate Positive (Outward) Venous Remodeling in a Mouse Model of Arteriovenous Fistula (AVF) Stenosis. J Am Soc Nephrol 2023; 34:532. [FR-PO470]
  10. Sudarsanam VA, Wai C, Sidhu J, Celdran-Bonafonte D, Arteaga EC, Xi G, Roy-Chaudhury P, Shebuski R, Uriyanghai U. Local Sirolimus Delivery Reduces Stenosis in a Pig Arteriovenous Graft (AVG) Model. J Am Soc Nephrol 2023; 34:533. [FR-PO471]
  11. Arteaga EC, Wai C, Uriyanghai U, Sudarsanam VA, Roy-Chaudhury P, Xi G. Phenotypic switch study in cultured arterial and venous SMCs: messages for the future development of novel therapies for vascular access dysfunction. J Am Soc Nephrol 2023; 34:537. [FR-PO488]
  12. Selvakumar PP, Uriyanghai U, Johnson RD, Wai C, Roy-Chaudhury P, Tan W. Biofunctionalized Vascular Access Graft Enhanced Patency and Endothelialization in a Pig Arteriovenous (AV) Model. J Am Soc Nephrol 2022; 33:7. [TH-OR20]
  13. Koury M, Pergola PE, Roy-Chaudhury P, Farag YM, Lou W, Anders R, Solinsky C, Vargo D, Winkelmayer WC. Iron-related outcomes in patients with non-dialysis dependent CKD randomized to vadadustat vs. darbopoietin alfa. J Am Soc Nephrol 2021; 32:190. {PO0482]
  14. Chertow GM. PRO2TECT Author Group. Global phase 3 clinical trials of vadadustat vs. darbepoetin alfa for treatment of anemia in patients with non-dialysis-dependent CKD. 2020; FR-OR54. Late-breaking abstract.
  15. Lewis TB, Jarrouj A, Wang LH, Campos B, Saum KL, Janda J, Owens AP, Roy-Chaudhury P, Celdran-Bonafonte D. Uremia induces functional and histological changes in a mouse model of arteriovenous fistula (AVF) stenosis. J Am Soc Nephrol 2019; 30:197. [TH-PO321]
  16. Roy-Chaudhury P, Saad TF, Trerotola SO on behalf of the Lutonix AV IDE investigators and the Medical Advisory Board. No increase in all-cause mortality from paclitaxel coated balloons (DCB) used in an arteriovenous circuit in dialysis patients. J Am Soc Nephrol 2019; 30:204. [TH-PO343]
  17. Chan JS, Roy-Chaudhury P, Wu T-c. The effect of sodium glucose co-transporter-2 inhibitor in angiogenesis of diabetic cardiovascular disease. J Am Soc Nephrol 2019; 30:844. [SA-PO314]